眼部附属器IgG4相关疾病的辅助性眼眶放射治疗：对皮质类固醇治疗难治或不耐受患者的初步经验
Adjunctive Orbital Radiotherapy for Ocular Adnexal IgG4-related Disease: Preliminary Experience in Patients Refractory or Intolerant to Corticosteroid Therapy.
作者信息
Lin Yu-Hao, Yen Sang-Hue, Tsai Chieh-Chih, Kao Shu-Ching, Lee Fenq-Lih
机构信息
Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University , Taipei , Taiwan and.
出版信息
Ocul Immunol Inflamm. 2015 Apr;23(2):162-7. doi: 10.3109/09273948.2014.928735. Epub 2014 Jul 10.
PURPOSE
To present the clinical outcomes of combined orbital radiotherapy and systemic corticosteroid for patients with refractory ocular adnexal IgG4-related disease.
METHODS
We retrospectively reviewed 3 patients with histopathologically confirmed ocular adnexal IgG4-related disease who had been refractory or intolerant to corticosteroid therapy and treated with adjunctive orbital radiotherapy (2000 cGy; 10 fractions). Clinical improvement was assessed by monitoring the patient's ability to taper corticosteroid to discontinuation and by follow-up radiologic examination.
RESULTS
All 3 patients had a favorable response to adjunctive radiotherapy with improvement of the clinical symptoms and radiologic abnormalities. Systemic corticosteroid was tapered and discontinued in all patients successfully. There were no adverse effects of treatment or recurrence after a mean follow-up of 19 months.
CONCLUSION
Adjunctive radiotherapy can help to achieve stable disease and cessation of systemic corticosteroid in patients with refractory ocular adnexal IgG4-related disease.
目的
介绍眼眶放疗联合全身用糖皮质激素治疗难治性眼眶附件IgG4相关疾病患者的临床疗效。
方法
我们回顾性分析了3例经组织病理学确诊的眼眶附件IgG4相关疾病患者，这些患者对糖皮质激素治疗难治或不耐受，并接受了辅助眼眶放疗（2000 cGy；10次分割）。通过监测患者逐渐减少糖皮质激素用量直至停药的能力以及随访影像学检查来评估临床改善情况。
结果
所有3例患者对辅助放疗均有良好反应，临床症状和影像学异常均有改善。所有患者均成功逐渐减少并停用了全身用糖皮质激素。平均随访19个月后，未出现治疗不良反应或复发。
结论
辅助放疗有助于难治性眼眶附件IgG4相关疾病患者实现病情稳定并停用全身用糖皮质激素。
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