汞制剂对胡子鲶（Clarias batrachus (L.)）甲状腺功能的毒性作用。

Toxic effects of mercurials on thyroid function of the catfish, Clarias batrachus (L.).

作者信息

Kirubagaran R, Joy K P

机构信息

Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India.

出版信息

Ecotoxicol Environ Saf. 1989 Jun;17(3):265-71. doi: 10.1016/0147-6513(89)90046-8.

DOI:10.1016/0147-6513(89)90046-8

PMID:2501079

Abstract

The toxic effects of mercurials on the thyroid activity of Clarias batrachus were evaluated after exposure for 45, 90, and 180 days during gonadal recrudescence. Histologically, the thyroid follicles were active with hypertrophied epithelium and reduced colloid content in 90- and 180-day mercuric chloride (HgCl2)- and 90-day methylmercuric chloride (CH3HgCl)-treated fish. In 180-day CH3HgCl and 90- and 180-day emisan 6 groups, the follicular epithelium appeared atrophic with a wavy and irregular outline and with hypertrophied and hyperplastic cells present in some parts of the epithelium. Thyroidal 131I uptake was inhibited in all groups and at all durations. Protein-bound iodine (PBI) levels decreased significantly in the 45-day CH3HgCl group and in all the mercurial groups treated for 90 and 180 days. Of the three mercurials, CH3HgCl was found to be more toxic than the other two in inhibiting thyroidal 131I uptake and PBI level at all durations.

摘要

在性腺再发育期间，对胡子鲶暴露于汞45天、90天和180天后汞对其甲状腺活性的毒性作用进行了评估。组织学上，在经90天和180天氯化汞（HgCl2）以及90天甲基汞（CH3HgCl）处理的鱼中，甲状腺滤泡活跃，上皮细胞肥大，胶体含量减少。在经180天CH3HgCl以及90天和180天埃米散6处理的组中，滤泡上皮出现萎缩，轮廓呈波浪状且不规则，上皮某些部位存在肥大和增生细胞。所有组在所有时间段甲状腺对131I的摄取均受到抑制。在45天CH3HgCl组以及所有经90天和180天处理的汞组中，蛋白结合碘（PBI）水平显著降低。在所有时间段，三种汞中，CH3HgCl在抑制甲状腺对131I的摄取和PBI水平方面比其他两种汞毒性更大。