Rho相关卷曲螺旋结构域蛋白激酶（ROCK）：结构、调节及功能
Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.
作者信息
Julian Linda, Olson Michael F
机构信息
Beatson Institute for Cancer Research; Glasgow, UK.
出版信息
Small GTPases. 2014;5:e29846. doi: 10.4161/sgtp.29846. Epub 2014 Jul 10.
Abstract
Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase. (1)(-) (5) They belong to the AGC family of serine/threonine kinases (6) and play vital roles in facilitating actomyosin cytoskeleton contractility downstream of RhoA and RhoC activation. Since their discovery, ROCK kinases have been extensively studied, unveiling their manifold functions in processes including cell contraction, migration, apoptosis, survival, and proliferation. Two mammalian ROCK homologs have been identified, ROCK1 (also called ROCK I, ROKβ, Rho-kinase β, or p160ROCK) and ROCK2 (also known as ROCK II, ROKα, or Rho kinase), hereafter collectively referred to as ROCK. In this review, we will focus on the structure, regulation, and functions of ROCK.
摘要
Rho相关卷曲螺旋结构域蛋白激酶（ROCK）最初被鉴定为RhoA小GTP酶的效应器。（1）（-）（5）它们属于丝氨酸/苏氨酸激酶的AGC家族（6），在RhoA和RhoC激活下游促进肌动球蛋白细胞骨架收缩中发挥重要作用。自发现以来，ROCK激酶已得到广泛研究，揭示了它们在细胞收缩、迁移、凋亡、存活和增殖等过程中的多种功能。已鉴定出两种哺乳动物ROCK同源物，ROCK1（也称为ROCK I、ROKβ、Rho激酶β或p160ROCK）和ROCK2（也称为ROCK II、ROKα或Rho激酶），以下统称为ROCK。在本综述中，我们将重点关注ROCK的结构、调节和功能。
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