顺式-2-氟环丙烷羧酸的立体选择性合成。
Stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid.
作者信息
Shibue Taku, Fukuda Yasumichi
机构信息
Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd. , 2399-1, Nogi, Nogi-Machi, Shimotsuga-Gun, Tochigi, 329-0114, Japan.
出版信息
J Org Chem. 2014 Aug 1;79(15):7226-31. doi: 10.1021/jo501219n. Epub 2014 Jul 18.
PMID:25010939
Abstract
A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopropanation of electron-deficient olefin and diazoacetates.
摘要
铑催化的1-氟-1-(苯磺酰基)乙烯与重氮酯的环丙烷化反应被描述为立体选择性合成顺式-2-氟环丙烷羧酸的有效方法。该过程提供了缺电子烯烃与重氮乙酸酯环丙烷化反应的一个实例。
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