Towers Greg J, Noursadeghi Mahdad
Division of Infection and Immunity, University College London, London W1CE 6BT, UK.
Division of Infection and Immunity, University College London, London W1CE 6BT, UK.
Cell Host Microbe. 2014 Jul 9;16(1):10-8. doi: 10.1016/j.chom.2014.06.009.
HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.
1984年，人类免疫缺陷病毒1型（HIV-1）被确认为艾滋病的病因。尽管经过30年的深入研究，我们仍在解析宿主与病原体相互作用的分子细节，正是这些相互作用使得这种病毒能够逃避免疫清除并导致免疫缺陷。在此，我们探讨了一系列近期研究，这些研究关注HIV-1在进出宿主细胞的过程中如何与细胞自主的固有免疫系统相互作用。我们讨论了这些研究如何增进我们对HIV-1和宿主生物学的认识，以及如何加深我们对病毒传播、持续存在和免疫缺陷的理解，以及治疗或预防干预的潜力。
