Okamura K
Third Department of Internal Medicine, Asahikawa Medical College, Japan.
Gastroenterol Jpn. 1989 Apr;24(2):181-94. doi: 10.1007/BF02774195.
A single intravenous injection of 4-hydroxyaminoquinoline-1-oxide (4-HAQO) induced a dose-dependent diffuse pancreatic acinar cell necrosis within 48 hours after the administration in rats. Regeneration following the necrosis ensued by 72 hours. The serum amylase levels were markedly elevated within 24 hours, which paralleled a decrease of digestive enzyme contents in the pancreas. The change of these biochemical parameters corresponded well with the morphological change of the pancreas. Autoradiographic studies with 3H-thymidine revealed that the labeling index of the regenerating acinar cells was considerably higher, reaching a peak value of nearly 18.2% at 72 hours after injection of 4-HAQO and it still remained high in 2.67% even at 168 hours after injection.
单次静脉注射4-羟基氨基喹啉-1-氧化物（4-HAQO）可在给药后48小时内在大鼠体内诱导剂量依赖性的弥漫性胰腺腺泡细胞坏死。72小时后坏死组织开始再生。血清淀粉酶水平在24小时内显著升高，这与胰腺中消化酶含量的降低相平行。这些生化参数的变化与胰腺的形态学变化非常吻合。用3H-胸腺嘧啶进行的放射自显影研究表明，再生腺泡细胞的标记指数相当高，在注射4-HAQO后72小时达到近18.2%的峰值，即使在注射后168小时仍有2.67%的细胞保持高标记指数。
