Rao M S, Reddy J K
J Pathol. 1976 Oct;120(2):109-14. doi: 10.1002/path.1711200206.
4-hydroxyaminoquinoline, a carcinogen was injected into guinea-pigs intravenously in a single dose of 22-5 mg/kg. The sequential morphological changes in the exocrine cells of the pancreas were studied by electron microscopy at selected intervals between 18 and 60 hr. The earliest alterations in the acinar cells comprised nucleolar segregation into granular and fibrillar components and minimal dilatation of endoplasmic reticulum. At later intervals all the cytoplasmic organelles appeared altered. The endoplasmic reticular channels were markedly dilated with depletion of membrane bound and free ribosomes. The mitochondria were swollen and irregular with disruption of limiting membranes and cristae. The zymogen granules were markedly reduced or completely absent. The hyaloplasm contained morphologically variable cytoplasmic degenerative bodies. In addition to the acinar cells, centriacinar and ductal epithelial cells showed similar changes.
将致癌物质4-羟基氨基喹啉以22.5毫克/千克的单剂量静脉注射到豚鼠体内。在18至60小时的选定间隔时间，通过电子显微镜研究胰腺外分泌细胞的连续形态变化。腺泡细胞最早的改变包括核仁分离为颗粒状和纤维状成分以及内质网的最小扩张。在随后的间隔时间，所有细胞质细胞器都出现了改变。内质网通道明显扩张，膜结合核糖体和游离核糖体减少。线粒体肿胀且形态不规则，其界膜和嵴遭到破坏。酶原颗粒明显减少或完全缺失。透明质质中含有形态多样的细胞质退化小体。除腺泡细胞外，中央腺泡细胞和导管上皮细胞也表现出类似变化。
