Pal Rameswar, Singh Som Nath, Chatterjee Abhirup, Saha Mantu
Centre for Advanced Research and Training in Yoga (CARTY), Defence Institute of Physiology and Allied Sciences (DIPAS), Lucknow Road, Timarpur, Delhi, 110054, India.
Age (Dordr). 2014;36(4):9683. doi: 10.1007/s11357-014-9683-7. Epub 2014 Jul 11.
Aging is associated with decline in cardiovascular, autonomic function, and brain-derived neurotropic factor (BDNF). Reports are scanty regarding whether yoga can improve age-related degenerative changes in healthy active men. This study is designed to appraise the role of yoga in improving age-related degenerative changes in cardiometabolic risk profile, autonomic function, stress, and BDNF. Healthy active males of three age groups (20-29, 30-39, and 40-49 years) were randomly assigned to practice yoga daily 1 h for 3 months. Significantly higher values of heart rate (HR), blood pressure (BP), load in heart (DoP), myocardial oxygen consumption (RPP), and total cholesterol (TC) were noted in senior age group. HR, BP, DoP, RPP, and TC decreased significantly following yogic practice. High frequency (HF), total power (TP), all time domain variables of heart rate variability (HRV), and skin conductance (SC) were significantly decreased with advancement of age. HF, TP, and time domain parameters of HRV and SC increased significantly following yogic practice. Higher levels of catecholamines and low frequency (LF) power of HRV was noted with advancement of age. Levels of catecholamines and LF significantly decreased following yogic practice. Cortisol and adrenocorticotropic hormone (ACTH) level raised in senior age group. BDNF, serotonin, and dopamine were low in higher age group. Significant decrement of cortisol; ACTH; and increment in serotonin, dopamine, and BDNF was noted following yogic practice. This study revealed that yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.
衰老与心血管功能、自主神经功能以及脑源性神经营养因子（BDNF）的衰退有关。关于瑜伽是否能改善健康活跃男性与年龄相关的退行性变化的报道很少。本研究旨在评估瑜伽在改善与年龄相关的心脏代谢风险状况、自主神经功能、压力和BDNF退行性变化中的作用。将三个年龄组（20 - 29岁、30 - 39岁和40 - 49岁）的健康活跃男性随机分配，每天进行1小时瑜伽练习，持续3个月。老年组的心率（HR）、血压（BP）、心脏负荷（DoP）、心肌耗氧量（RPP）和总胆固醇（TC）值显著更高。瑜伽练习后，HR、BP、DoP、RPP和TC显著降低。随着年龄的增长，高频（HF）、总功率（TP）、心率变异性（HRV）的所有时域变量以及皮肤电导率（SC）显著降低。瑜伽练习后，HF、TP以及HRV和SC的时域参数显著增加。随着年龄的增长，儿茶酚胺水平升高，HRV的低频（LF）功率增加。瑜伽练习后，儿茶酚胺水平和LF显著降低。老年组的皮质醇和促肾上腺皮质激素（ACTH）水平升高。高龄组的BDNF、血清素和多巴胺水平较低。瑜伽练习后，皮质醇、ACTH显著降低，血清素、多巴胺和BDNF增加。这项研究表明，瑜伽练习可能通过改变健康男性的心脏代谢危险因素、自主神经功能和BDNF来帮助预防与年龄相关的退化。
