BfS Bundesamt für Strahlenschutz/Federal Office for Radiation Protection, Department of Radiation and Health , Oberschleißheim , Germany.
Int J Radiat Biol. 2014 Nov;90(11):1114-8. doi: 10.3109/09553002.2014.943850.
To develop a compartmental model of the systemic biokinetics of tellurium required for calculating the internal dose and interpreting bioassay measurements after incorporation of radioactive tellurium.
The compartmental model for tellurium was developed with the software SAAM II v. 2.0 (©The Epsilon Group, Charlottesville, Virginia, USA). Model parameters were determined on the basis of published retention and excretion data in humans and animals.
The model consists of two blood compartments, one compartment each for liver, kidneys, thyroid, four compartments for bone tissues and a generic compartment for the soft tissues. The model predicts a rapid urinary excretion of systemic tellurium: 45% in the first 24 h and 84% after 50 d. Faecal excretion amounts to 0.4% after 3 d and 9% after 50 d. Whole body retention is 55% after one day, and 2.8% after 100 d. These values as well as the retained fractions in the single organs are reasonably consistent with the available human and animal data (studies with swine and guinea pigs).
The proposed model gives a realistic description of the available biokinetic data for tellurium and will be adopted by the International Commission on Radiological Protection for applications in internal dosimetry.
开发一个用于计算放射性碲摄入后体内剂量和解释生物检测结果的全身性生物动力学碲模型。
使用 SAAM II v. 2.0 软件（美国弗吉尼亚州夏洛茨维尔的 Epsilon 集团版权所有）开发了碲的房室模型。模型参数是基于人类和动物的发表的滞留和排泄数据来确定的。
该模型由两个血液室、一个肝脏室、一个肾脏室、一个甲状腺室、四个骨骼室和一个通用软组织室组成。该模型预测系统性碲的快速尿液排泄：24 小时内排泄 45%，50 天后排泄 84%。粪便排泄量在 3 天后为 0.4%，50 天后为 9%。一天后全身滞留量为 55%，100 天后为 2.8%。这些值以及单个器官中的滞留分数与现有的人类和动物数据（猪和豚鼠研究）相当一致。
所提出的模型对碲的可用生物动力学数据进行了合理的描述，将被国际辐射防护委员会采用用于内部剂量学应用。
