Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel (VUB) Brussels/Faculté de Psychologie et des sciences de l'éducation, Place du Parc, 20 UMons, Mons, Belgium
Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Mult Scler. 2015 Jan;21(1):83-91. doi: 10.1177/1352458514537012. Epub 2014 Jul 10.
Cognitive impairment affects half of the multiple sclerosis (MS) patient population and is an important contributor to patients' daily activities. Most cognitive impairment studies in MS are, however, cross-sectional or/and focused on the early disease stages.
We aim to assess the time course of decline of different cognitive domains.
We collected neuropsychological data on 514 MS patients to construct Kaplan-Meier survival curves of the tests included in the Neuropsychological Screening Battery for MS (NSBMS) and the Symbol Digit Modalities Test (SDMT). Cox-proportional hazard models were constructed to examine the influence of MS onset type, age at onset, gender, depression and level of education on the time course, expressed as age or disease.
Survival curves of tests focusing on information processing speed (IPS) declined significantly faster than tests with less specific demands of IPS. Median age for pathological decline was 56.2 years (95% CI: 54.4-58.2) on the SDMT and 63.9 years (95% CI: 60-66.9) on the CLTR, a memory task.
In conclusion, IPS is the cognitive domain not only most widely affected by MS but it is also the first cognitive deficit to emerge in MS.
认知障碍影响了一半的多发性硬化症（MS）患者，并对患者的日常活动产生重要影响。然而，大多数 MS 认知障碍研究都是横断面研究，或者/并且集中在疾病早期阶段。
我们旨在评估不同认知领域的衰退时间过程。
我们收集了 514 名 MS 患者的神经心理学数据，构建了包含在多发性硬化症神经心理学筛查测试（NSBMS）和符号数字模态测试（SDMT）中的测试的 Kaplan-Meier 生存曲线。构建 Cox 比例风险模型来检查 MS 发病类型、发病年龄、性别、抑郁和教育水平对时间过程的影响，用年龄或疾病表示。
专注于信息处理速度（IPS）的测试的生存曲线明显比 IPS 需求较少的测试下降得更快。在 SDMT 上，病理性下降的中位年龄为 56.2 岁（95%CI：54.4-58.2），在记忆任务 CLTR 上为 63.9 岁（95%CI：60-66.9）。
综上所述，IPS 不仅是受 MS 影响最广泛的认知领域，也是 MS 中最早出现的认知缺陷。
