乙肝感染对肾移植结局的影响：一项长期研究。

The impact of hepatitis B infection on outcome of kidney transplantation: a long-term study.

作者信息

Einollahi B, Alavian S M, Lessan-Pezeshki M, Simforoosh N, Nourbala M H, Rostami Z, Pourfarziani V, Nemati E, Sharafi M, Nafar M, Pour-Reza Gholi F, Firoozan A

机构信息

Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

出版信息

Int J Organ Transplant Med. 2010;1(2):91-3.

PMID:25013571

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4089227/

Abstract

BACKGROUND

With the success of kidney transplantation, liver disease has emerged as an important cause of morbidity and mortality in kidney recipients.

OBJECTIVE

To determine the impact of hepatitis B virus (HBV) infection on patients and graft survival in both short- and long-terms.

METHODS

99 renal transplant patients infected with HBV on follow-up in two major transplant centers were included in a retrospective study. These patients were grafted between 1986 and 2005 and divided into two groups: (1) those only positive for hepatitis B surface antigen (HBsAg) and (2) those who were also positive for hepatitis C virus antibodies (HCV Ab).

RESULTS

There were 88 patients with HBsAg(+) and 11 with both HBsAg(+) and HCV Ab(+). The mean±SD age of patients was 38.8±13.2 years, and the median follow-up after transplantation was 19 months. Although not significant, the allograft survival rate in the first group (HBV(+)) was better compared to that in the second group (HBV(+) and HCV(+)); 1, 5 and 10 years graft survival rates were 91, 77 and 62 in the first group and 70, 56 and 28 in the second group, respectively (P=0.07). The overall mortality was 5% (4 of 88) in the first and 27% (3 of 11) in the second group (P=0.02).

CONCLUSION

Renal allograft recipients with HBV and HCV infections has a poor survival rate compared to patients with only HBV infection. However, there is no significant difference in terms of renal graft survival between the two groups.

摘要

背景

随着肾移植的成功，肝脏疾病已成为肾移植受者发病和死亡的重要原因。

目的

确定乙型肝炎病毒（HBV）感染对患者短期和长期生存及移植物存活的影响。

方法

一项回顾性研究纳入了在两个主要移植中心随访的99例感染HBV的肾移植患者。这些患者于1986年至2005年间接受移植，并分为两组：（1）仅乙肝表面抗原（HBsAg）阳性者；（2）同时丙肝病毒抗体（HCV Ab）阳性者。

结果

88例患者HBsAg阳性，11例患者HBsAg和HCV Ab均阳性。患者的平均±标准差年龄为38.8±13.2岁，移植后的中位随访时间为19个月。第一组（HBV（+））的同种异体移植物存活率虽与第二组（HBV（+）和HCV（+））相比无显著差异，但相对较好；第一组1年、5年和10年的移植物存活率分别为91%、77%和62%，第二组分别为70%、56%和28%（P=0.07）。第一组的总死亡率为5%（88例中的4例），第二组为27%（11例中的3例）（P=0.02）。