肥胖与慢性病的预后——心肺适能在肥胖悖论中的影响
Obesity and prognosis in chronic diseases--impact of cardiorespiratory fitness in the obesity paradox.
作者信息
Lavie Carl J, Schutter Alban De, Archer Edward, McAuley Paul A, Blair Steven N
机构信息
1Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - University of Queensland School of Medicine, New Orleans, LA; 2Department of Preventive Medicine, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; 3Office of Energetics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL; 4Department of Health, Physical Education, and Sports Sciences, Winston-Salem State University, Winston-Salem, NC; and 5Department of Exercise Science and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.
出版信息
Curr Sports Med Rep. 2014 Jul-Aug;13(4):240-5. doi: 10.1249/JSR.0000000000000067.
The effects of overweight and obesity on chronic diseases, particularly on cardiovascular disease (CVD), and its impact on increasing CVD risk factors and total CVD are reviewed. However despite the adverse effects of obesity on CVD risk factors and CVD, obesity has a surprising association with prognosis in patients with established diseases, often showing an "obesity paradox," [corrected] where overweight (body mass index (BMI), 25 to 29.9 kg·m(-2)) and obese patients (BMI, ≥30 kg·m(-2)) with established CVD frequently have a better prognosis than that of their leaner counterparts (BMI, <25 kg·m(-2)) with the same diseases. Fitness-versus-fatness debate is summarized also, including the critical role that fitness plays to alter the relationship between adiposity and subsequent prognosis.
本文综述了超重和肥胖对慢性疾病的影响，尤其是对心血管疾病（CVD）的影响，以及其对增加CVD危险因素和总体CVD的作用。然而，尽管肥胖对CVD危险因素和CVD有不良影响，但肥胖与已确诊疾病患者的预后存在惊人的关联，常表现为“肥胖悖论”，即患有CVD的超重（体重指数（BMI）为25至29.9kg·m-2）和肥胖患者（BMI≥30kg·m-2）往往比患有相同疾病的较瘦患者（BMI<25kg·m-2）预后更好。本文还总结了健康与肥胖的争论，包括健康在改变肥胖与后续预后之间关系中所起的关键作用。
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