Bera Kalisankar, Namboothiri Irishi N N
Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
Org Biomol Chem. 2014 Sep 7;12(33):6425-31. doi: 10.1039/c4ob00344f.
Michael addition of α-nitrosulfones to aryl- and alkyl acrylates and acrylamides proceeds in the presence of 5-10 mol% of an amino acid derived new organocatalyst to provide γ-tetrasubstituted γ-nitro-γ-sulfonyl carboxylates and amides in excellent yields and enantioselectivities. Scale-up of the reaction to multi-grams, convenient recovery of the catalyst and its recyclability without any drop in yield and selectivity are attractive features of this methodology.
在5-10摩尔%的氨基酸衍生新型有机催化剂存在下，α-亚硝基砜与芳基丙烯酸酯和烷基丙烯酸酯以及丙烯酰胺进行迈克尔加成反应，以优异的产率和对映选择性生成γ-四取代的γ-硝基-γ-磺酰基羧酸盐和酰胺。该反应放大至数克规模、催化剂易于回收及其可循环使用且产率和选择性无任何下降是该方法的吸引人之处。
