Key Laboratory of Biomedical Polymers, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.
Org Lett. 2017 Oct 6;19(19):5130-5133. doi: 10.1021/acs.orglett.7b02417. Epub 2017 Sep 11.
The nickel-catalyzed asymmetric hydrogenation of β-(acylamino)acrylates has been developed, affording chiral β-amino acid derivatives with excellent yields (95-99% yield) and enantioselectivities (97-99% ee). With the Ni-Binapine system, high enantioselectivities (98-99% ee) have also been obtained in the hydrogenation of Z/E isomeric mixtures of β-alkyl and β-aryl β-(acylamino)acrylates. The synthesis of chiral β-amino acid derivatives on a gram scale has also been achieved with 0.2 mol % catalyst loading.
已开发出镍催化的β-（酰氨基）丙烯酸盐的不对称氢化反应，以优异的收率（95-99%收率）和对映选择性（97-99%ee）得到手性β-氨基酸衍生物。使用 Ni-Binapine 体系，在氢化 Z/E 异构体混合物的β-烷基和β-芳基β-（酰氨基）丙烯酸盐时也获得了高对映选择性（98-99%ee）。在手性β-氨基酸衍生物的克级规模合成中，催化剂用量为 0.2mol%时也能实现。
