从耐盐真菌青霉中合成 Chrysogeside B 及其抗菌活性评价。
Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation.
机构信息
Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
Nutrichem Company Limited, No. 27 Life Sciences Park Road, Changping District, Beijing 102206, P.R. China.
出版信息
Sci Rep. 2017 Apr 11;7:45927. doi: 10.1038/srep45927.
Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impact on the antimicrobial activities. The synthesis of Chrysogeside B and analogues designed to allow identification of the features of this glycolipid required for recognition by tested bacteria and Hela cells is described.
胆甾烷苷 B 是一种天然的脑苷脂，可通过商业原料高效合成。生物活性测试表明，化合物 4、5 和 6 的生物活性优于胆甾烷苷 B。进一步的研究表明，游离羟基和糖苷键对其抗菌活性有显著影响。本文描述了胆甾烷苷 B 及其类似物的合成，旨在确定该糖脂被测试细菌和 Hela 细胞识别所必需的特征。
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