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从耐盐真菌青霉中合成 Chrysogeside B 及其抗菌活性评价。

Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation.

机构信息

Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.

Nutrichem Company Limited, No. 27 Life Sciences Park Road, Changping District, Beijing 102206, P.R. China.

出版信息

Sci Rep. 2017 Apr 11;7:45927. doi: 10.1038/srep45927.

DOI:10.1038/srep45927
PMID:28397807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5387731/
Abstract

Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impact on the antimicrobial activities. The synthesis of Chrysogeside B and analogues designed to allow identification of the features of this glycolipid required for recognition by tested bacteria and Hela cells is described.

摘要

胆甾烷苷 B 是一种天然的脑苷脂，可通过商业原料高效合成。生物活性测试表明，化合物 4、5 和 6 的生物活性优于胆甾烷苷 B。进一步的研究表明，游离羟基和糖苷键对其抗菌活性有显著影响。本文描述了胆甾烷苷 B 及其类似物的合成，旨在确定该糖脂被测试细菌和 Hela 细胞识别所必需的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/c499354245f7/srep45927-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/61378e04750a/srep45927-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/e3f0aedd4553/srep45927-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/ec96fb106e66/srep45927-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/6debc297e15f/srep45927-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/225287ffa6e9/srep45927-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/75ae36ebe54f/srep45927-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/7b95639c7f92/srep45927-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/c499354245f7/srep45927-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/61378e04750a/srep45927-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/e3f0aedd4553/srep45927-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/ec96fb106e66/srep45927-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/6debc297e15f/srep45927-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/225287ffa6e9/srep45927-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/75ae36ebe54f/srep45927-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/7b95639c7f92/srep45927-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b01/5387731/c499354245f7/srep45927-f8.jpg

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本文引用的文献

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Synthesis of α-L-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibodies.
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Design and Evaluation of ω-Hydroxy Fatty Acids Containing α-GalCer Analogues for CD1d-Mediated NKT Cell Activation.含α-半乳糖神经酰胺类似物的ω-羟基脂肪酸用于CD1d介导的NKT细胞激活的设计与评估
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Influence of nonionic branched-chain alkyl glycosides on a model nano-emulsion for drug delivery systems.非离子支链烷基糖苷对药物传递系统模型纳米乳液的影响。
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