Pritz Theresa, Weinberger Birgit, Grubeck-Loebenstein Beatrix
Institute for Biomedical Aging Research, Universität Innsbruck, Rennweg 10, Innsbruck, Austria.
Institute for Biomedical Aging Research, Universität Innsbruck, Rennweg 10, Innsbruck, Austria.
Immunol Lett. 2014 Nov;162(1 Pt B):310-5. doi: 10.1016/j.imlet.2014.06.016. Epub 2014 Jul 8.
With aging the immune system undergoes significant age-related changes. These age-dependent changes are referred to as immunosenescence and are partially responsible for the poor immune response to infections and the low efficacy of vaccination in elderly persons. Immunosenescence is characterized by a decrease in innate and adaptive cell-mediated immune function in the peripheral blood and the bone marrow. The aging of bone marrow cells and in particular, of adaptive immune cells in the bone marrow has been addressed relatively rarely. It is therefore the goal of this review to summarize what is known about the effect of age on bone marrow immune cells and their precursors in mice and humans.
随着年龄增长，免疫系统会经历显著的与年龄相关的变化。这些与年龄相关的变化被称为免疫衰老，部分原因是老年人对感染的免疫反应不佳以及疫苗接种效果低下。免疫衰老的特征是外周血和骨髓中固有和适应性细胞介导的免疫功能下降。骨髓细胞的衰老，尤其是骨髓中适应性免疫细胞的衰老，相对较少受到关注。因此，本综述的目的是总结关于年龄对小鼠和人类骨髓免疫细胞及其前体细胞影响的已知情况。
