Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, 430022, China.
Bone Res. 2024 Aug 5;12(1):42. doi: 10.1038/s41413-024-00346-4.
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including the skeletal and immune systems. Recent studies have elucidated the intricate bidirectional interactions between these two systems. In this review, we provide a comprehensive synthesis of molecular mechanisms of cell ageing. We further discuss how age-related skeletal changes influence the immune system and the consequent impact of immune system alterations on the skeletal system. Finally, we highlight the clinical implications of these findings and propose potential strategies to promote healthy ageing and reduce pathologic deterioration of both the skeletal and immune systems.
衰老是一个自然的、不可逆转的过程，会导致许多器官系统和组织的功能恶化，包括骨骼和免疫系统。最近的研究阐明了这两个系统之间复杂的双向相互作用。在这篇综述中，我们提供了细胞衰老分子机制的综合综合。我们进一步讨论了与年龄相关的骨骼变化如何影响免疫系统，以及免疫系统变化对骨骼系统的后续影响。最后，我们强调了这些发现的临床意义，并提出了促进骨骼和免疫系统健康衰老和减少病理性恶化的潜在策略。
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