对间日疟原虫/卵形疟原虫感染治疗管理建议的依从性。

Compliance to recommendations for the management of curative treatment of Plasmodium vivax/ovale infections.

作者信息

Faucher J-F, Bellanger A-P, Shaniya N, Hustache-Mathieu L, Hoen B, Chirouze C

机构信息

Service des maladies infectieuses et tropicales, CHRU Jean-Minjoz, 3, boulevard Fleming, 25030 Besançon, France.

Laboratoire de parasitologie-mycologie, CHRU Jean-Minjoz, 25030 Besançon, France.

出版信息

Med Mal Infect. 2014 Aug;44(8):387-9. doi: 10.1016/j.medmal.2014.06.006. Epub 2014 Jul 9.

DOI:10.1016/j.medmal.2014.06.006

PMID:25015307

Abstract

OBJECTIVES

We assessed the compliance to recommendations for the routine management of Plasmodium vivax/ovale malaria, and analyzed the impact of discrepancies on the quality of care.

PATIENTS AND METHODS

We reviewed the cases of P. ovale and P. vivax malaria treated at the Besançon University Hospital, France (2008-2013).

RESULTS

Chloroquine was prescribed in 44% of the 18 cases (4 due to P. ovale, 14 to P. vivax). Radical cure with primaquine was prescribed after the first bout of malaria for 6 patients. The primaquine dose prescribed was inferior to the recommended one for 4 patients. The mean delay between schizonticide treatment and primaquine cure was 43 days.

CONCLUSIONS

The delay before access to primaquine radical cure was the only parameter, likely to alter treatment effectiveness, but also difficult to shorten. Future national guidelines should take into account that not all patients have access to primaquine treatment immediately after schizonticide treatment.

摘要