Dastagir Ghulam, Hussain Farrukh
Pharmacognosy Lab., Department of Botany, University of Peshawar, KPK, Pakistan.
Pak J Pharm Sci. 2014 Jul;27(4):801-5.
The methanolic and n-hexane extracts of studied plants showed significant toxicity to brine shrimps. The methanolic extract of Fagonia cretica had highest LD50 (117.72) value, while Peganum harmala showed low LD50 value (41.70) compared to n-hexane extract. The methanolic and n-hexane extracts of Tribulus terrestris showed similar LD50 values. The methanolic extract of Chrozophora tinctoria showed low LD50 value than the n-hexane extract. The methanolic extract of Ricinus communis showed highest LD50 value while the n-hexane extract showed lowest LD50 value. The LD50 value less than 100 was obtained for n-hexane extracts of Fagonia cretica, Peganum harmala and Ricinus communis. The n-hexane extracts of these plants also showed the highest toxicity as compare to methanolic extracts. The chemical constituents detected in the present investigation might be responsible for cytotoxic activity.
所研究植物的甲醇提取物和正己烷提取物对卤虫显示出显著毒性。刺山柑的甲醇提取物具有最高的半数致死剂量（LD50）值（117.72），而与正己烷提取物相比，骆驼蓬的LD50值较低（41.70）。刺蒺藜的甲醇提取物和正己烷提取物显示出相似的LD50值。染用蓝蓟的甲醇提取物的LD50值低于正己烷提取物。蓖麻的甲醇提取物显示出最高的LD50值，而正己烷提取物显示出最低的LD50值。刺山柑、骆驼蓬和蓖麻的正己烷提取物的LD50值小于100。与甲醇提取物相比，这些植物的正己烷提取物也显示出最高的毒性。本研究中检测到的化学成分可能是细胞毒性活性的原因。
