EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.
作者信息
Matsuo Hidemasa, Kajihara Mio, Tomizawa Daisuke, Watanabe Tomoyuki, Saito Akiko Moriya, Fujimoto Junichiro, Horibe Keizo, Kodama Kumi, Tokumasu Mayu, Itoh Hiroshi, Nakayama Hideki, Kinoshita Akitoshi, Taga Takashi, Tawa Akio, Taki Tomohiko, Shiba Norio, Ohki Kentaro, Hayashi Yasuhide, Yamashita Yuka, Shimada Akira, Tanaka Shiro, Adachi Souichi
机构信息
Department of Human Health Sciences, Kyoto University, Japan.
Department of Pediatrics, Tokyo Medical and Dental University (TMDU), Japan.
出版信息
Haematologica. 2014 Nov;99(11):e225-7. doi: 10.3324/haematol.2014.107128. Epub 2014 Jul 11.
Abstract
摘要
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EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.EVI1过表达是混合谱系白血病-AF9重排急性髓系白血病患儿的不良预后因素。
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本文引用的文献
1
Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group.诱导治疗中适当的剂量减少对于治疗急性髓细胞白血病的婴儿至关重要：来自日本儿科白血病/淋巴瘤研究组的报告。
Int J Hematol. 2013 Nov;98(5):578-88. doi: 10.1007/s12185-013-1429-2. Epub 2013 Sep 26.
2
High EVI1 expression is associated with MLL rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology group.EVI1 高表达与 MLL 重排相关，并预示着儿科急性髓系白血病患者生存时间缩短：来自儿童肿瘤协作组的报告。
Br J Haematol. 2013 Sep;162(5):670-7. doi: 10.1111/bjh.12444. Epub 2013 Jul 4.
3
Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group.EVI1 表达失调定义了伴有 MLL 重排的急性髓系白血病预后不良的亚群：德国-奥地利急性髓系白血病研究组和荷兰-比利时-瑞士 HOVON/SAKK 合作组的研究。
J Clin Oncol. 2013 Jan 1;31(1):95-103. doi: 10.1200/JCO.2011.41.5505. Epub 2012 Sep 24.
4
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.EVI1 对于一小部分 MLL-AF9 重排 AML 的发病机制至关重要。
Blood. 2012 Jun 14;119(24):5838-49. doi: 10.1182/blood-2011-11-393827. Epub 2012 May 2.
5
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.Evi1 对于造血干细胞自我更新是必需的，其表达标志着具有长期多谱系重建造血活性的造血细胞。
J Exp Med. 2011 Nov 21;208(12):2403-16. doi: 10.1084/jem.20110447. Epub 2011 Nov 14.
6
Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia.EVI1 的下调与急性髓系白血病患者的表观遗传改变和良好预后相关。
Haematologica. 2011 Oct;96(10):1448-56. doi: 10.3324/haematol.2011.040535. Epub 2011 Jul 12.
7
CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.CD52 作为免疫治疗靶点治疗高 EVI1 表达的急性髓系白血病。
Leukemia. 2011 Jun;25(6):921-31. doi: 10.1038/leu.2011.36. Epub 2011 Mar 11.
8
Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells.Evi-1 是造血干细胞中混合谱系白血病癌蛋白的转录靶标。
Blood. 2011 Jun 9;117(23):6304-14. doi: 10.1182/blood-2009-07-234310. Epub 2010 Dec 29.
9
EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia.EVI1 在不同亚型的小儿急性髓系白血病中的过表达。
Leukemia. 2010 May;24(5):942-9. doi: 10.1038/leu.2010.47. Epub 2010 Apr 1.
10
High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities.EVI1 高表达可预测年轻成人急性髓系白血病患者的预后，并与独特的细胞遗传学异常相关。
J Clin Oncol. 2010 Apr 20;28(12):2101-7. doi: 10.1200/JCO.2009.26.0646. Epub 2010 Mar 22.
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