Kurdistani Siavash K
Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Curr Opin Genet Dev. 2014 Jun;26:53-8. doi: 10.1016/j.gde.2014.06.002. Epub 2014 Jul 10.
Cancer tissues with lower global levels of histone acetylation display significantly increased rate of tumor recurrence or cancer-related mortality. The function global regulation of histone acetylation serves for the cell or how lower levels of histone acetylation may contribute to a more aggressive cancer phenotype has been unclear. Chromatin and histone modifications are currently thought to regulate only DNA-based processes. However, recent findings have revealed a novel function for global histone acetylation in direct regulation of cellular physiology. I will discuss how chromatin, by regulating the cellular flux of acetate, may integrate control of cellular physiologic state with gene expression and help explain the observations in cancer tissues.
组蛋白乙酰化整体水平较低的癌组织显示出肿瘤复发率或癌症相关死亡率显著增加。组蛋白乙酰化的整体调节功能对细胞的作用，或者较低水平的组蛋白乙酰化如何导致更具侵袭性的癌症表型，目前尚不清楚。染色质和组蛋白修饰目前被认为仅调节基于DNA的过程。然而，最近的研究结果揭示了整体组蛋白乙酰化在直接调节细胞生理方面的新功能。我将讨论染色质如何通过调节乙酸盐的细胞通量，将细胞生理状态的控制与基因表达整合起来，并有助于解释在癌组织中的观察结果。
