组蛋白甲基化：在健康、疾病和遗传中的动态标记。
Histone methylation: a dynamic mark in health, disease and inheritance.
机构信息
Cell Biology Department, Harvard Medical School and Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
出版信息
Nat Rev Genet. 2012 Apr 3;13(5):343-57. doi: 10.1038/nrg3173.
Abstract
Organisms require an appropriate balance of stability and reversibility in gene expression programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation is integral to this dynamic control. Post-translational modification of histones by methylation is an important and widespread type of chromatin modification that is known to influence biological processes in the context of development and cellular responses. To evaluate how histone methylation contributes to stable or reversible control, we provide a broad overview of how histone methylation is regulated and leads to biological outcomes. The importance of appropriately maintaining or reprogramming histone methylation is illustrated by its links to disease and ageing and possibly to transmission of traits across generations.
摘要
生物体需要在基因表达程序中保持适当的稳定性和可逆性平衡，以维持细胞的身份或对刺激做出反应; 表观遗传调控是这种动态控制的重要组成部分。组蛋白的翻译后修饰，如甲基化，是一种重要且广泛存在的染色质修饰类型，已知在发育和细胞反应的背景下影响生物过程。为了评估组蛋白甲基化如何有助于稳定或可逆的控制，我们提供了一个广泛的概述，说明组蛋白甲基化是如何被调控的，并导致生物学结果。通过将其与疾病和衰老联系起来，并可能与跨代传递特征联系起来，说明了适当维持或重新编程组蛋白甲基化的重要性。
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