Malec Michalina, Malec Michalina, Rudzińska Monika, Dudek Dominika, Siwek Marcin, Wnuk Marcin, Szczudlik Andrzej
Psychiatr Pol. 2014 Mar-Apr;48(2):299-306.
Systemic Lupus Erythematosus (SLE) is autoimmunological disease of connective tissue which is characterized with clinical symptoms of many systems and organs injury. There are often neuropsychiatric symptoms. Psychotic disorder is the least frequent syndrome. Neuropsychiatric symptoms are important because they deteriorate the quality of life and are poor prognostic factor.
The aim of the study is to present the patient with chronic, lasting for many years, skin lesions and laboratory tests results characteristic for SLE, who had psychotic disorder diagnosed as schizophrenia and in the next few years there were observed other neuropsychiatric symptoms including cognitive impairment and mood disorder.
Psychotic disorder is rare syndrome of neuropsychiatric SLE (NPSLE). It may primarily originate from SLE or be secondary either to the therapy or the complications of the disease. It is not possible to define if the psychosis is the primary schizophrenic process or secondary to the autoimmune disease in presented patient. However the clinical picture pays attention to the significance of careful diagnostic process, including neuroimaging. In head CT of presented patient there were revealed massive, bilateral, calcifications of subcortical structures which probably substantially enhanced neuropsychiatric symptoms.
系统性红斑狼疮（SLE）是一种结缔组织自身免疫性疾病，其特征是多个系统和器官受损的临床症状。常伴有神经精神症状。精神障碍是最不常见的综合征。神经精神症状很重要，因为它们会降低生活质量且是不良预后因素。
本研究的目的是介绍一名患有慢性、持续多年的皮肤病变以及具有SLE特征性实验室检查结果的患者，该患者被诊断为精神分裂症的精神障碍，并且在接下来的几年中还观察到其他神经精神症状，包括认知障碍和情绪障碍。
精神障碍是神经精神性SLE（NPSLE）中罕见的综合征。它可能主要源于SLE，或者继发于治疗或疾病并发症。在该患者中，无法确定精神障碍是原发性精神分裂症过程还是继发于自身免疫性疾病。然而，临床表现提醒我们注意仔细诊断过程的重要性，包括神经影像学检查。在该患者的头部CT中，发现双侧皮质下结构有大量钙化，这可能在很大程度上加重了神经精神症状。
