Łukaszyk Ewelina, Małyszko Jolanta
Przegl Lek. 2014;71(2):95-7.
Subclinical inflammation is one of the key mechanisms responsible for the development and progression of chronic kidney disease. It may stem from uremia, ongoing inflammation in kidney as well as latent bacterial and viral infections. Inflammation also plays a significant role in the pathogenesis of anemia of chronic disease through its impact on the iron metabolism. The paper presents the current knowledge concerning the involvement of iron in the development of anemia in chronic kidney disease, with particular reference to the role of hepcidin in systemic iron circulation.
亚临床炎症是慢性肾脏病发生和进展的关键机制之一。它可能源于尿毒症、肾脏持续存在的炎症以及潜伏的细菌和病毒感染。炎症通过对铁代谢的影响，在慢性病贫血的发病机制中也起着重要作用。本文介绍了目前关于铁在慢性肾脏病贫血发生中的作用的知识，特别提及了铁调素在全身铁循环中的作用。
