Mogadam Reza Alipanah, Nemati Ali, Amani Firouz, Ghorbanihaghjo Amir, Argani Hassan, Bashardoust Bahman
Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Pak Med Assoc. 2015 Apr;65(4):354-7.
To explore the probable association of serum hepcidin and haemoglobin levels with iron and inflammation statuses in patients of chronic kidney disease stage 4 with anaemia.
The cross-sectional study was conducted at Tabriz University of Medical Sciences, Iran, from March 2011 to October 2012, and comprised patients of chronic kidney disease stage 4 with anaemia. Serum biochemical factors as well as hepcidin, ferritin, interleukin 6, high sensitivity C-reactive protein and iron levels were measured using standard methods. Statistical correlations were established using regression analysis and Pearson's correlation coefficient.
There were 40 patients among whom 15(37.5%) were males and 25(62.5%) were females with an overall mean age of 55.68±14.4 years. There was a significant inverse relationship between hepcidin and haemoglobin levels (p<0.05). There were significant correlations between hepcidin with iron status, nutritional and inflammatory markers such as ferritin, Total iron binding capacity, albumin and interleukin 6 (p<0.05 each).
Hepcidin had negative correlation with haemoglobin level in stage 4 chronic kidney disease patients with adequate iron stores, which could be effective in the development of anaemia in such patients.
探讨慢性肾脏病4期贫血患者血清铁调素和血红蛋白水平与铁及炎症状态之间可能存在的关联。
2011年3月至2012年10月在伊朗大不里士医科大学开展了一项横断面研究，研究对象为慢性肾脏病4期贫血患者。采用标准方法测量血清生化因子以及铁调素、铁蛋白、白细胞介素6、高敏C反应蛋白和铁水平。使用回归分析和Pearson相关系数建立统计相关性。
共有40例患者，其中男性15例（37.5%），女性25例（62.5%），总体平均年龄为55.68±14.4岁。铁调素与血红蛋白水平之间存在显著负相关（p<0.05）。铁调素与铁状态、营养和炎症标志物如铁蛋白、总铁结合力、白蛋白和白细胞介素6之间存在显著相关性（各p<0.05）。
在铁储备充足的慢性肾脏病4期患者中，铁调素与血红蛋白水平呈负相关，这可能对这类患者贫血的发生发展有影响。
