Hernigou Philippe, Flouzat-Lachaniette Charles-Henri, Delambre Jerome, Poignard Alexandre, Allain Jerome, Chevallier Nathalie, Rouard Helene
Orthopaedic Surgery, University Paris East, Hôpital Henri Mondor, 94010 Creteil, France.
University Paris East, Hôpital Henri Mondor, 94010 Creteil, France.
Bone. 2015 Jan;70:102-9. doi: 10.1016/j.bone.2014.04.034. Epub 2014 Jul 10.
Hip osteonecrosis is a pathological condition resulting from cellular impairment due to reduction in osteoblast activity and local mesenchymal stem cell populations. Cell-based therapies might aid in overcoming these deficiencies by providing stem cells and other progenitor cells to potentially improve the local cellular environment in the affected hip.
A PubMed search, using the search terms "hip osteonecrosis" and "mesenchymal stem cells", was conducted in December 2013. A total of 15 publications were identified and reviewed for clinical outcomes.
Clinical studies of patients with osteonecrosis treated with mesenchymal stem cells showed beneficial effects. No unexpected adverse events were identified in these studies. Core decompression was the usual method for autologous bone marrow cell implantation into the femoral head. However, other methods have been used such as arterial or venous delivery. A rationale for the use of cytotherapy, as well as the different descriptions of the techniques of implantation MSCs (autologous vs. allogenic, concentration vs. expansion), is provided in the context of treating hip osteonecrosis. Current problems and future challenges with cytotherapy and associated techniques are discussed. This article is part of a Special Issue entitled "Stem Cells and Bones".
髋部骨坏死是一种病理状态，由成骨细胞活性降低和局部间充质干细胞数量减少导致的细胞损伤引起。基于细胞的疗法可能有助于克服这些缺陷，通过提供干细胞和其他祖细胞来潜在地改善受影响髋部的局部细胞环境。
2013年12月在PubMed上进行检索，使用检索词“髋部骨坏死”和“间充质干细胞”。共识别出15篇出版物并对其临床结果进行了综述。
间充质干细胞治疗骨坏死患者的临床研究显示出有益效果。这些研究中未发现意外不良事件。髓芯减压是将自体骨髓细胞植入股骨头的常用方法。然而，也使用了其他方法，如动脉或静脉输送。在治疗髋部骨坏死的背景下，提供了细胞疗法的应用原理以及间充质干细胞植入技术的不同描述（自体与异体、浓度与扩增）。讨论了细胞疗法及相关技术当前存在的问题和未来挑战。本文是名为“干细胞与骨骼”的特刊的一部分。
