Gottlich Caleb P, Fisher John C, Diab Michel
Orthopedic Surgery Texas Tech University Health Sciences Center.
Orthop Rev (Pavia). 2024 Mar 24;16:115354. doi: 10.52965/001c.115354. eCollection 2024.
Acute Lymphoblastic Leukemia is the most prevalent pediatric hematologic malignancy. The treatment for this illness has advanced significantly, now touting a 90% cure rate. Although these patients often become disease free, treatment can leave devastating effects that last long after their disease burden is alleviated. A commonly experienced result of treatment is osteonecrosis (ON), often occurring in weight bearing joints. Uncertainty exists in the optimal treatment of this cohort of patients. In this review, we describe the etiology and suspected pathogenesis of ON, as well as treatment options described in the literature.
急性淋巴细胞白血病是最常见的儿童血液系统恶性肿瘤。针对这种疾病的治疗已经取得了显著进展，目前治愈率高达90%。尽管这些患者通常能够实现疾病缓解，但治疗可能会留下严重的影响，在疾病负担减轻后的很长时间内依然存在。治疗中常见的一个结果是骨坏死（ON），常发生于负重关节。对于这组患者的最佳治疗方案尚存在不确定性。在本综述中，我们描述了骨坏死的病因和疑似发病机制，以及文献中所述的治疗选择。
