Laue Svenja, Winterhoff Moritz, Kaever Volkhard, van den Heuvel Jeroen J, Russel Frans G, Seifert Roland
Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 2014 Sep;387(9):893-5. doi: 10.1007/s00210-014-1018-9. Epub 2014 Jul 15.
The cyclic pyrimidine nucleotide cCMP has been suggested to serve as second messenger. However, phosphodiesterases studied so far do not hydrolyze cCMP. Therefore, we searched for alternative cCMP inactivation mechanisms. cCMP is a substrate for multidrug resistance protein 5, indicating that export from the cytosol into the extracellular space is an important inactivation mechanism for cCMP.
环状嘧啶核苷酸cCMP被认为可作为第二信使。然而，迄今为止所研究的磷酸二酯酶并不水解cCMP。因此，我们寻找cCMP的其他失活机制。cCMP是多药耐药蛋白5的底物，这表明从细胞质转运到细胞外空间是cCMP的一种重要失活机制。
