Chiriac Anca M, Demoly Pascal
Allergy Unit, Respiratoty and Addictology Department, Hôpital Arnaud de Villeneuve, 371, Avenue du Doyen Gaston Giraud, University Hospital of Montpellier Cedex 5, Montpellier 34295, France.
Allergy Unit, Respiratoty and Addictology Department, Hôpital Arnaud de Villeneuve, 371, Avenue du Doyen Gaston Giraud, University Hospital of Montpellier Cedex 5, Montpellier 34295, France; Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, Paris 75013, France.
Immunol Allergy Clin North Am. 2014 Aug;34(3):461-71, vii. doi: 10.1016/j.iac.2014.03.002. Epub 2014 May 27.
Poorly documented and often self-reported drug hypersensitivity (DH) is a frequent problem in daily clinical practice and has a considerable impact on prescription choices. Little is known about the natural history of true DH. The suspicion of DH starts on clinical grounds. When assessing a patient with a presumed DH reaction in the symptomatic phase, it is mandatory to look for severity signs and, after doing so, to update the risk/benefit balance of exploring the suspected drug(s) on a case-by-case basis. With the help of allergy tests and a careful approach, a firm diagnosis is often possible.
记录不完善且常为自我报告的药物超敏反应（DH）在日常临床实践中是一个常见问题，对处方选择有相当大的影响。关于真正的DH的自然病程知之甚少。对DH的怀疑基于临床依据。在评估处于症状期的疑似DH反应患者时，必须寻找严重程度的迹象，在此之后，根据具体情况更新探究可疑药物的风险/收益平衡。借助过敏试验和谨慎的方法，通常可以做出明确诊断。
