Vultaggio Alessandra, Castells Mariana C
Immunoallergology Unit, Department of Biomedicine, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, Florence 50134, Italy.
Drug Hypersensitivity and Desensitization Center, Mastocytosis Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Immunol Allergy Clin North Am. 2014 Aug;34(3):615-32, ix. doi: 10.1016/j.iac.2014.04.008.
Biologic agents (BAs) are important therapeutic tools; their use has rapidly expanded and they are used in oncology, immunology, and inflammatory diseases. Their use may be limited, however, by adverse drug reactions. This article reviews the current literature on clinical presentation and pathogenic mechanisms of both acute and delayed reactions. In addition, procedures for management of BA-induced reactions, including preventive and diagnostic work-up, are provided. Lastly, this article summarizes the current knowledge of desensitization to several widely used monoclonal antibodies.
生物制剂（BAs）是重要的治疗工具；其应用迅速扩展，用于肿瘤学、免疫学和炎症性疾病。然而，其应用可能受到药物不良反应的限制。本文综述了关于急性和迟发性反应的临床表现及发病机制的当前文献。此外，还提供了生物制剂诱导反应的管理程序，包括预防性和诊断性检查。最后，本文总结了目前对几种广泛使用的单克隆抗体脱敏的认识。
