Molfino Alessio, Formiconi Alessandra, Rossi Fanelli Filippo, Muscaritoli Maurizio
Sapienza University of Rome, Department of Clinical Medicine , Viale dell'Università, 37, 00185 Roma , Italy +39 06 499 72016 ;
Expert Opin Biol Ther. 2014 Oct;14(10):1379-81. doi: 10.1517/14712598.2014.939068. Epub 2014 Jul 12.
Biological treatments represent a novel approach to counteract cancer cachexia. Monoclonal antibodies targeting cytokines and molecules responsible for muscle wasting, with an anti-inflammatory effect, however, still have several limitations and need further clinical investigation. New research in this field will contribute to the better understanding of the multifactorial pathogenesis of cancer cachexia, while favoring the consolidation of multimodal preventive and therapeutic strategies encompassing nutritional and pharmacological treatments. New pharmacological therapies and conventional nutritional treatments will soon integrate in the 'parallel pathway', aimed at early recognition, prevention and treatment of the metabolic and nutritional derangements occurring in cancer. This will likely produce improvement in quality of life, tolerance to treatments and survival.
生物治疗是对抗癌症恶病质的一种新方法。然而，靶向细胞因子和导致肌肉萎缩的分子的单克隆抗体具有抗炎作用，但仍有一些局限性，需要进一步的临床研究。该领域的新研究将有助于更好地理解癌症恶病质的多因素发病机制，同时有利于巩固包括营养和药物治疗在内的多模式预防和治疗策略。新的药物疗法和传统的营养治疗将很快整合到“平行途径”中，旨在早期识别、预防和治疗癌症中发生的代谢和营养紊乱。这可能会改善生活质量、提高治疗耐受性并延长生存期。
