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Regulation of ornithine decarboxylase in normal and neoplastic mouse and human epidermis.

作者信息

O'Brien T G, Dzubow L, Dlugosz A A, Gilmour S K, O'Donnell K, Hietala O

机构信息

Wistar Institute, Philadelphia, Pennsylvania 19104.

出版信息

Prog Clin Biol Res. 1989;298:213-31.

PMID:2501797
Abstract
摘要

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1
Regulation of ornithine decarboxylase in normal and neoplastic mouse and human epidermis.正常及肿瘤性小鼠和人表皮中鸟氨酸脱羧酶的调节
Prog Clin Biol Res. 1989;298:213-31.
2
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Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.在表皮中过表达蛋白激酶Cε的转基因小鼠在肿瘤促进后乳头状瘤负担减轻,但癌症形成增强。
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Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.α-二氟甲基鸟氨酸抑制蛋白激酶Cε转基因小鼠转移性鳞状细胞癌的发展,并伴有明显的毛囊退化和脱发。
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Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.蛋白激酶Cδ介导的向鸟氨酸脱羧酶诱导的信号传导独立于皮肤肿瘤抑制作用。
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