Chua Brendon Y, Brown Lorena E, Jackson David C
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia.
Expert Rev Vaccines. 2014 Nov;13(11):1327-37. doi: 10.1586/14760584.2014.938641. Epub 2014 Jul 12.
The threat of an outbreak of avian-origin influenza H7N9 and the devastating consequences that a pandemic could have on global population health and economies has mobilized programs of constant surveillance and the implementation of preemptive plans. Central to these plans is the production of prepandemic vaccines that can be rapidly deployed to minimize disease severity and deaths resulting from such an occurrence. In this article, we review current H7N9 vaccine strategies in place and the available technologies and options that can help accelerate vaccine production and increase dose-sparing capabilities to provide enough vaccines to cover the population. We also present possible means of reducing disease impact during the critical period after an outbreak occurs before a strain matched vaccine becomes available and consider the use of existing stockpiles and seed strains of phylogenetically related subtypes, alternate vaccination regimes and vaccine forms that induce cross-reactive immunity.
源自禽类的H7N9流感爆发的威胁以及大流行可能对全球人口健康和经济造成的毁灭性后果，促使了持续监测计划的开展和预防性计划的实施。这些计划的核心是生产大流行前疫苗，以便能够迅速部署，将此类事件导致的疾病严重程度和死亡人数降至最低。在本文中，我们回顾了当前现有的H7N9疫苗策略以及可用技术和选项，这些技术和选项有助于加快疫苗生产并提高剂量节省能力，从而提供足够的疫苗以覆盖人群。我们还提出了在毒株匹配疫苗可用之前的爆发关键期减少疾病影响的可能方法，并考虑使用系统发育相关亚型的现有储备和种子毒株、替代疫苗接种方案以及诱导交叉反应性免疫的疫苗形式。
