Chu Xue-Qiang, Meng Hua, Zi You, Xu Xiao-Ping, Ji Shun-Jun
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, People's Republic of China.
Chem Commun (Camb). 2014 Sep 4;50(68):9718-21. doi: 10.1039/c4cc04282d.
A metal-free method for direct C(sp(3))-H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.
描述了一种无金属方法，用于简单醚与α,α-二芳基烯丙醇的直接C(sp(3))-H键官能化。既定的方案通过自由基加成和1,2-芳基迁移级联过程，提供了一种简便的方法来制备α-芳基-β-氧烷基化羰基酮。该产物已在一种血清素拮抗剂的合成中得到应用。
