微小 RNA 在调节骨骼肌健康和疾病中的巨大作用。
Mega roles of microRNAs in regulation of skeletal muscle health and disease.
机构信息
Department of Biochemistry, YLL School of Medicine, National University of Singapore Singapore, Singapore.
Brenner Centre for Molecular Medicine, Singapore Institute for Clinical Sciences (ASTAR) Singapore, Singapore.
出版信息
Front Physiol. 2014 Jun 26;5:239. doi: 10.3389/fphys.2014.00239. eCollection 2014.
Abstract
Skeletal muscle is a dynamic tissue with remarkable plasticity. Skeletal muscle growth and regeneration are highly organized processes thus it is not surprising that a high degree of complexity exists in the regulation of these processes. Recent discovery of non-coding microRNAs (miRNAs) has prompted extensive research in understanding the roles of these molecules in skeletal muscle. Research so far shows that miRNAs play a very significant role at every aspect of muscle biology. Besides muscle growth, development, and regeneration miRNAs are also involved in the pathology of muscle diseases and metabolism. In this review, recent advancements in miRNA function during myogenesis, exercise, atrophy, aging, and dystrophy are discussed.
摘要
骨骼肌是一种具有显著可塑性的动态组织。骨骼肌的生长和再生是高度组织化的过程，因此，这些过程的调节存在高度的复杂性也就不足为奇了。最近非编码 microRNAs（miRNAs）的发现促使人们广泛研究这些分子在骨骼肌中的作用。迄今为止的研究表明，miRNAs 在肌肉生物学的各个方面都起着非常重要的作用。除了肌肉生长、发育和再生，miRNAs 还参与肌肉疾病和代谢的病理学。在这篇综述中，讨论了 miRNA 在成肌分化、运动、萎缩、衰老和营养不良过程中的功能的最新进展。
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