人脂肪源性干细胞的软骨分化：关节软骨缺损治疗的新途径？
Chondrogenic differentiation of human adipose-derived stem cells: a new path in articular cartilage defect management?
作者信息
Stromps Jan-Philipp, Paul Nora Emilie, Rath Björn, Nourbakhsh Mahtab, Bernhagen Jürgen, Pallua Norbert
机构信息
Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany ; Institute of Biochemistry and Molecular Cell Biology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
出版信息
Biomed Res Int. 2014;2014:740926. doi: 10.1155/2014/740926. Epub 2014 Jun 12.
According to data published by the Centers for Disease Control and Prevention, over 6 million people undergo a variety of medical procedures for the repair of articular cartilage defects in the U.S. each year. Trauma, tumor, and age-related degeneration can cause major defects in articular cartilage, which has a poor intrinsic capacity for healing. Therefore, there is substantial interest in the development of novel cartilage tissue engineering strategies to restore articular cartilage defects to a normal or prediseased state. Special attention has been paid to the expansion of chondrocytes, which produce and maintain the cartilaginous matrix in healthy cartilage. This review summarizes the current efforts to generate chondrocytes from adipose-derived stem cells (ASCs) and provides an outlook on promising future strategies.
根据美国疾病控制与预防中心公布的数据，美国每年有超过600万人接受各种修复关节软骨缺损的医疗手术。创伤、肿瘤以及与年龄相关的退变可导致关节软骨出现重大缺损，而关节软骨本身的愈合能力较差。因此，人们对开发新型软骨组织工程策略以将关节软骨缺损恢复至正常或疾病前状态有着浓厚兴趣。人们特别关注软骨细胞的扩增，软骨细胞在健康软骨中产生并维持软骨基质。本综述总结了目前从脂肪来源干细胞（ASC）生成软骨细胞的研究成果，并对未来有前景的策略进行了展望。
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