Mahadevan Brinda, Thorsrud Bjorn A, Brorby Gregory P, Ferguson Heather E
Regulatory Affairs, Abbott Nutrition, Abbott Laboratories, 3300 Stelzer Road, Columbus, OH 43219, USA.
MPI Research, Inc., 54943 North Main Street, Mattawan, MI 49071, USA.
Food Chem Toxicol. 2014 Oct;72:83-9. doi: 10.1016/j.fct.2014.07.009. Epub 2014 Jul 11.
Octenyl succinic anhydride (OSA)-modified starch functions as both an emulsifier and emulsion stabilizer in foods, and is intended for use in infant formula, follow-on formula, and formulae for special medical purposes. These formulae predominantly include extensively hydrolyzed protein or free amino acids, rather than intact protein, which otherwise would provide emulsifying functionality. The study objectives were to evaluate (1) the safety of OSA-modified starch after three weeks of administration to neonatal farm piglets, beginning 2 days after birth and (2) the impact of OSA-modified starch on piglet growth. OSA-modified starch was added to formula at concentrations of 2, 4, and 20 g/L. The vehicle control, low-dose, and mid-dose diets were supplemented with Amioca™ Powder to balance the nutritional profiles of all formulations. There were no test article-related effects of any diet containing OSA-modified starch on piglet growth and development (clinical observations, body weight, feed consumption), or clinical pathology parameters (hematology, clinical chemistry, coagulation, urinalysis). In addition, there were no adverse effects at terminal necropsy (macro- and microscopic pathology evaluations). Therefore, dietary exposure to OSA-modified starch at concentrations up to 20 g/L was well tolerated by neonatal farm piglets and did not result in adverse health effects or impact piglet growth.
辛烯基琥珀酸酐（OSA）改性淀粉在食品中兼具乳化剂和乳液稳定剂的功能，拟用于婴儿配方奶粉、较大婴儿配方奶粉和特殊医学用途配方食品。这些配方食品主要包含深度水解蛋白或游离氨基酸，而非完整蛋白质，否则后者会提供乳化功能。本研究的目的是评估：（1）出生后2天起，给新生仔猪连续喂食3周OSA改性淀粉后的安全性；（2）OSA改性淀粉对仔猪生长的影响。将OSA改性淀粉按2、4和20 g/L的浓度添加到配方食品中。在载体对照组、低剂量组和中剂量组的日粮中添加木薯淀粉（Amioca™ Powder），以平衡所有配方的营养成分。含OSA改性淀粉的任何日粮对仔猪生长发育（临床观察、体重、采食量）或临床病理学参数（血液学、临床化学、凝血、尿液分析）均无与受试物相关的影响。此外，在末次剖检时（大体和显微镜病理学评估）也未发现不良反应。因此，新生仔猪对日粮中浓度高达20 g/L的OSA改性淀粉具有良好的耐受性，未导致不良健康影响，也未影响仔猪生长。
