Ross D G, Heaton W A, Holme S
American Red Cross Blood Services, Tidewater Region, Norfolk, Va.
Vox Sang. 1989;56(2):75-9. doi: 10.1111/j.1423-0410.1989.tb04953.x.
The additive solution, ADSOL, was evaluated for its suitability in the extended storage of previously frozen, deglycerolized red blood cells. In vitro comparison with red cells suspended in 0.2% dextrose 0.9% saline showed that ADSOL allowed for significantly enhanced adenosine triphosphate preservation throughout the storage period (greater than 2.2 mumol/g Hb beyond 14 days) and for significantly reduced hemolysis (less than 1% beyond 14 days). After 10 days of storage in ADSOL the mean recovery after transfusion was 90% (index of therapeutic effectiveness, 77%). No bacterial contamination was observed. The results suggest that this currently approved additive solution could be used to store red cells for 14 days following thawing, thus avoiding one of the principal drawbacks of frozen red cells.
评估了添加剂溶液ADSOL在长期储存先前冷冻、去甘油化红细胞方面的适用性。与悬浮在0.2%葡萄糖0.9%盐水中的红细胞进行体外比较，结果表明，ADSOL在整个储存期内可显著增强三磷酸腺苷的保存效果（14天后大于2.2μmol/g血红蛋白），并显著降低溶血率（14天后小于1%）。在ADSOL中储存10天后，输血后的平均回收率为90%（治疗效果指数为77%）。未观察到细菌污染。结果表明，这种目前已获批准的添加剂溶液可用于解冻后红细胞的储存14天，从而避免了冷冻红细胞的一个主要缺点。
