Bondarenko V M, Alekseev Iu V, Mislavskiĭ O V, Ponomarev G V
Biomed Khim. 2014 May-Jun;60(3):338-47. doi: 10.18097/pbmc20146003338.
Effects of disodium salt 2,4-di(1-metoxyethyl)-deuteroporphyrine-IX (Dimegin) and the light from Soret band (»395-405 nm) at the viability of microbial cells and at their potential to form microbial biofilms have been compared with traditional antiseptics. Irradiation of microbial cells of S. aureus, E. coli, C. albicans and others with diode light (power density 0.05 Wt/cm2) caused a bactericidial effect similar to that obtained with standard anticeptics (chlorhexidine and dioxidine). A comparative study of the effectiveness of Dimegin and Photoditazine (a soluble salt of chlorine e6) as photosensitizers have been performed using the test system of erythrocyte hemolysis in vitro under irradiation with light from the Sore band. Results have shown insignificant difference in the photodynamic effect with similar doses of absorbed light and preparation concentration.
已将2,4-二（1-甲氧基乙基）-氘代卟啉-IX二钠盐（Dimegin）以及索雷特带（395 - 405纳米）的光对微生物细胞活力及其形成微生物生物膜潜力的影响与传统防腐剂进行了比较。用二极管光（功率密度0.05瓦/平方厘米）照射金黄色葡萄球菌、大肠杆菌、白色念珠菌等的微生物细胞，产生了与标准防腐剂（氯己定和二氧化氯）相似的杀菌效果。使用体外红细胞溶血测试系统，在索雷特带光照射下，对Dimegin和Photoditazine（氯e6的可溶性盐）作为光敏剂的有效性进行了比较研究。结果表明，在相似的吸收光剂量和制剂浓度下，光动力效应差异不显著。
