Conte G, Vazzola A, Sacchetti E
Institute of Psychiatry, University of Milan, Italy.
Acta Psychiatr Scand. 1989 May;79(5):503-4. doi: 10.1111/j.1600-0447.1989.tb10295.x.
We investigated the renal function (urine volume, glomerular filtration rate, urinary osmolality and proteinuria) of 50 patients chronically treated with lithium carbonate for major affective disorder. No patient had any alteration in the parameters considered. No relationship was found between any of the parameters studied and duration of illness or lithium levels, both in serum and red blood cells. These results were confirmed by the administration of the DDAVP test to 10 patients of the original sample; no alteration of concentration ability was found. We suggest that the discrepancy between our findings and those of most authors was a result of the serum lithium level of our patient sample, which was lower than that usually used in other studies.
我们调查了50例因重度情感障碍长期接受碳酸锂治疗的患者的肾功能（尿量、肾小球滤过率、尿渗透压和蛋白尿）。在所考虑的参数方面，没有患者出现任何改变。在研究的任何参数与病程或血清及红细胞中的锂水平之间均未发现相关性。对原始样本中的10例患者进行去氨加压素试验，证实了这些结果；未发现浓缩能力有改变。我们认为，我们的研究结果与大多数作者的结果之间存在差异，是由于我们患者样本的血清锂水平低于其他研究中通常使用的水平。
