Ohnishi Kotaro, Semi Katsunori, Yamada Yasuhiro
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8507, Japan.
Biochem Biophys Res Commun. 2014 Dec 5;455(1-2):10-5. doi: 10.1016/j.bbrc.2014.07.020. Epub 2014 Jul 11.
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the transient expression of reprogramming factors. During the reprogramming process, somatic cells acquire the ability to undergo unlimited proliferation, which is also an important characteristic of cancer cells, while their underlying DNA sequence remains unchanged. Based on the characteristics shared between pluripotent stem cells and cancer cells, the potential involvement of the factors leading to reprogramming toward pluripotency in cancer development has been discussed. Recent in vivo reprogramming studies provided some clues to understanding the role of reprogramming-related epigenetic regulation in cancer development. It was shown that premature termination of the in vivo reprogramming result in the development of tumors that resemble pediatric cancers. Given that epigenetic modifications play a central role during reprogramming, failed reprogramming-associated cancer development may have provided a proof of concept for epigenetics-driven cancer development in vivo.
通过重编程因子的瞬时表达，体细胞可被重编程为诱导多能干细胞（iPSC）。在重编程过程中，体细胞获得了无限增殖的能力，这也是癌细胞的一个重要特征，而其潜在的DNA序列保持不变。基于多能干细胞和癌细胞之间的共同特征，人们讨论了导致向多能性重编程的因素在癌症发展中的潜在作用。最近的体内重编程研究为理解重编程相关的表观遗传调控在癌症发展中的作用提供了一些线索。研究表明，体内重编程的过早终止会导致类似于儿童癌症的肿瘤发生。鉴于表观遗传修饰在重编程过程中起核心作用，与重编程失败相关的癌症发展可能为体内表观遗传学驱动的癌症发展提供了一个概念验证。
