Narkpuk Jaraspim, Wanitchang Asawin, Kramyu Jarin, Frantz Phanramphoei Namprachan, Jongkaewwattana Anan, Teeravechyan Samaporn
Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
Biochem Biophys Res Commun. 2014 Aug 8;450(4):1469-74. doi: 10.1016/j.bbrc.2014.07.022. Epub 2014 Jul 11.
While viral inhibition by tethering of budding virions to host cell membranes has been focused upon as one of the main functions of BST-2/tetherin, BST-2 is thought to possess other functions as well. Overexpression of BST-2 was found here to down-regulate transient protein expression. Removal of the N- and C-terminal regions of BST-2, previously described to be involved in signal transduction, reduced the impact of BST-2. These results suggest that BST-2-mediated signaling may play a role in regulating the levels of transiently expressed proteins, highlighting a new function for BST-2 that may also have implications for viral inhibition.
虽然通过将出芽病毒体拴系到宿主细胞膜上来抑制病毒已被视为BST-2/栓系蛋白的主要功能之一，但人们认为BST-2也具有其他功能。在此发现BST-2的过表达会下调瞬时蛋白表达。去除先前描述的参与信号转导的BST-2的N端和C端区域，可降低BST-2的影响。这些结果表明，BST-2介导的信号传导可能在调节瞬时表达蛋白的水平中发挥作用，这突出了BST-2的一项新功能，该功能可能也与病毒抑制有关。
