Autret E, Forveille-Fournier E, Marchand S, Jonville A P, Ramponi N
Services de Pharmacologie Clinique, Hôpital Bretonneau, Tours.
Arch Fr Pediatr. 1989 Apr;46(4):271-2.
Nestosyl is usually used for dental pain in children. We report a methemoglobinemia after accidental ingestion of 10 ml in a 2 year-old girl. Cyanosis was cleared and O2 saturation and PaO2 were normalized 15 mn after methylene blue (1 mg/kg) administered intravenously. Nestosyl contains butoform, benzocaine, resorcine and 8-hydroxyquinoleine: the 3 latest can induce methemoglobinemia. The benefit of the drug is not demonstrated and this potentially severe side effect justifies its delivery only after medical prescription and information about its dangers.
内斯托西尔通常用于治疗儿童牙痛。我们报告了一名2岁女孩意外摄入10毫升该药物后发生高铁血红蛋白血症的病例。静脉注射亚甲蓝（1毫克/千克）15分钟后，发绀消失，血氧饱和度和动脉血氧分压恢复正常。内斯托西尔含有布托仿、苯佐卡因、间苯二酚和8-羟基喹啉：后三种成分可诱发高铁血红蛋白血症。该药物的益处尚未得到证实，这种潜在的严重副作用说明只有在医生处方并告知其风险后才能使用。
