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普萘洛尔预防非肝硬化性门脉纤维化患者静脉曲张再出血的对照试验。

Controlled trial of propranolol to prevent recurrent variceal bleeding in patients with non-cirrhotic portal fibrosis.

作者信息

Kiire C F

机构信息

Department of Medicine, University of Zimbabwe, Harare.

出版信息

BMJ. 1989 May 20;298(6684):1363-5. doi: 10.1136/bmj.298.6684.1363.

DOI:10.1136/bmj.298.6684.1363
PMID:2502256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1836658/
Abstract

Fifty patients with non-cirrhotic portal fibrosis who were admitted to hospital because of upper gastrointestinal bleeding were randomly assigned to treatment with either oral propranolol given in doses that reduced the resting pulse rate by 25% (25 patients) or with a placebo (25 patients). One year after the start of the study 20 patients in the propranolol group and five patients in the placebo group were free from recurrent gastrointestinal bleeding (p less than 0.0001). Giving continuous oral propranolol treatment is therefore effective in preventing recurrent upper gastrointestinal bleeding in patients with non-cirrhotic portal fibrosis.

摘要

50例因上消化道出血入院的非肝硬化性门脉纤维化患者被随机分为两组，一组口服普萘洛尔，剂量以使静息心率降低25%为准（25例患者），另一组服用安慰剂（25例患者）。研究开始一年后，普萘洛尔组有20例患者、安慰剂组有5例患者未再发生胃肠道出血（P<0.0001）。因此，持续口服普萘洛尔治疗对预防非肝硬化性门脉纤维化患者上消化道出血复发有效。

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本文引用的文献

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Comparison of the effects of a cardioselective and a nonselective beta-blocker on portal hypertension in patients with cirrhosis.比较一种心脏选择性β受体阻滞剂和一种非选择性β受体阻滞剂对肝硬化患者门静脉高压的影响。
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Selective and non-selective beta receptor blockade in the reduction of portal pressure in patients with cirrhosis and portal hypertension.选择性和非选择性β受体阻滞剂降低肝硬化和门静脉高压患者门静脉压力的作用
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