阴离子非双层磷脂在强化外膜通透性屏障中的新作用。
Emerging roles for anionic non-bilayer phospholipids in fortifying the outer membrane permeability barrier.
作者信息
Bishop Russell E
机构信息
Department of Biochemistry and Biomedical Sciences, and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
出版信息
J Bacteriol. 2014 Sep;196(18):3209-13. doi: 10.1128/JB.02043-14. Epub 2014 Jul 14.
Abstract
Lately, researchers have been actively investigating Escherichia coli lptD mutants, which exhibit reduced transport of lipopolysaccharide to the cell surface. In this issue of the Journal of Bacteriology, Sutterlin et al. (H. A. Sutterlin, S. Zhang, and T. J. Silhavy, J. Bacteriol. 196:3214-3220, 2014) now reveal an important functional role for phosphatidic acid in fortifying the outer membrane permeability barrier in certain lptD mutant backgrounds. These findings come on the heels of the first reports of two LptD crystal structures, which now provide a structural framework for interpreting lptD genetics.
摘要
最近，研究人员一直在积极研究大肠杆菌lptD突变体，这些突变体表现出脂多糖向细胞表面的转运减少。在本期《细菌学杂志》中，萨特林等人（H. A. 萨特林、S. 张和T. J. 西尔哈维，《细菌学杂志》196:3214 - 3220，2014年）现在揭示了磷脂酸在某些lptD突变背景下强化外膜通透性屏障中的重要功能作用。这些发现紧跟在两篇LptD晶体结构的首次报道之后，这两篇报道现在为解释lptD遗传学提供了一个结构框架。
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