≥50岁成年人社区队列中接受医学治疗的呼吸道合胞病毒感染的季节性发病率。
Seasonal incidence of medically attended respiratory syncytial virus infection in a community cohort of adults ≥50 years old.
作者信息
McClure David L, Kieke Burney A, Sundaram Maria E, Simpson Melissa D, Meece Jennifer K, Sifakis Frangiscos, Gasser Robert A, Belongia Edward A
机构信息
Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America.
MedImmune LLC, Gaithersburg, Maryland, United States of America.
出版信息
PLoS One. 2014 Jul 15;9(7):e102586. doi: 10.1371/journal.pone.0102586. eCollection 2014.
BACKGROUND
Diagnostic testing for respiratory syncytial virus (RSV) is not routinely performed in adults. We estimated medically attended RSV seasonal incidence in a community cohort of adults ≥50 years old during four influenza seasons (2006-07 through 2009-10).
METHODS
Patients seeking care for acute respiratory illness (ARI) were prospectively enrolled and tested for RSV by multiplex RT-PCR. Results from enrolled patients were used to estimate projected cases among non-enrolled patients with ARI. The seasonal incidence of medically attended RSV was the sum of actual and projected cases divided by the community cohort denominator. Since each enrollment period did not include the entire RSV season, incidence estimates were adjusted to account for the statewide proportion of RSV occurring outside the study enrollment period.
RESULTS
There were 16,088 to 17,694 adults in the cohort each season and 164 RSV cases in all 4 seasons. The overall seasonal incidence of medically attended RSV was 154 episodes (95% CI, 132-180) per 10,000 persons; the incidence was highest in 2007-08 (179) and lowest in 2006-07 (110). Among persons 50-59, 60-69, and ≥70 years old, RSV incidence was 124 (95% CI, 99-156), 147 (95% CI, 110-196), and 199 (95% CI, 153-258), respectively.
CONCLUSIONS
The incidence of medically attended RSV increased with age and was similar during four seasons.
背景
呼吸道合胞病毒（RSV）诊断检测在成人中并非常规开展。我们估算了在四个流感季节（2006 - 07年至2009 - 10年）中，年龄≥50岁的社区成年人群体中因就医而诊断出的RSV季节性发病率。
方法
前瞻性纳入因急性呼吸道疾病（ARI）就诊的患者，并通过多重逆转录聚合酶链反应（RT-PCR）检测RSV。纳入患者的检测结果用于估算未纳入的ARI患者中的预计病例数。因就医而诊断出的RSV季节性发病率为实际病例数与预计病例数之和除以社区群体分母。由于每个纳入期并未涵盖整个RSV季节，发病率估算值进行了调整，以考虑全州范围内在研究纳入期之外发生的RSV比例。
结果
每个季节队列中有16,088至17,694名成年人，四个季节共有164例RSV病例。因就医而诊断出的RSV总体季节性发病率为每10,000人154例（95%置信区间，132 - 180）；发病率在2007 - 08年最高（179例），在2006 - 07年最低（110例）。在50 - 59岁、60 - 69岁和≥70岁的人群中，RSV发病率分别为124例（95%置信区间，99 - 156）、147例（95%置信区间，110 - 196）和199例（95%置信区间，153 - 258）。
结论
因就医而诊断出的RSV发病率随年龄增长而增加，且在四个季节中相似。
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