老年人因呼吸道合胞病毒、人偏肺病毒和流感病毒而住院的比率。
Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults.
机构信息
Department of Medicine, VA TN Valley Health Care System, Nashville, Tennessee 37205, USA.
出版信息
J Infect Dis. 2012 Jul 1;206(1):56-62. doi: 10.1093/infdis/jis309. Epub 2012 Apr 23.
BACKGROUND
We performed a prospective study to determine the disease burden of respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) in older adults in comparison with influenza virus.
METHODS
During 3 consecutive winters, we enrolled Davidson County (Nashville, TN) residents aged ≥ 50 years admitted to 1 of 4 hospitals with acute respiratory illness (ARI). Nasal/throat swabs were tested for influenza, RSV, and HMPV with reverse-transcriptase polymerase chain reaction. Hospitalization rates were calculated.
RESULTS
Of 1042 eligible patients, 508 consented to testing. Respiratory syncytial virus was detected in 31 participants (6.1%); HMPV was detected in 23 (4.5%) patients; and influenza was detected in 33 (6.5%) patients. Of those subjects aged ≥ 65 years, 78% received influenza vaccination. Compared with patients with confirmed influenza, patients with RSV were older and more immunocompromised; patients with HMPV were older, had more cardiovascular disease, were more likely to have received the influenza vaccination, and were less likely to report fever than those with influenza. Over 3 years, average annual rates of hospitalization were 15.01, 9.82, and 11.81 per 10,000 county residents due to RSV, HMPV, and influenza, respectively.
CONCLUSIONS
In adults aged ≥ 50 years, hospitalization rates for RSV and HMPV were similar to those associated with influenza.
背景
我们进行了一项前瞻性研究，以确定呼吸道合胞病毒（RSV）和人类偏肺病毒（HMPV）在老年人中的疾病负担，与流感病毒进行比较。
方法
在连续三个冬季，我们招募了年龄≥50 岁的戴维森县（纳什维尔，田纳西州）居民，他们因急性呼吸道疾病（ARI）入住了 4 家医院中的 1 家。使用逆转录-聚合酶链反应（RT-PCR）对鼻/咽拭子进行流感、RSV 和 HMPV 的检测。计算住院率。
结果
在 1042 名符合条件的患者中，有 508 名同意接受检测。在 31 名参与者（6.1%）中检测到呼吸道合胞病毒；在 23 名（4.5%）患者中检测到 HMPV；在 33 名（6.5%）患者中检测到流感。在≥65 岁的患者中，78%接受了流感疫苗接种。与确诊流感的患者相比，RSV 患者年龄更大，免疫功能更低下；HMPV 患者年龄更大，患有更多心血管疾病，更有可能接种流感疫苗，且发热的可能性低于流感患者。在 3 年期间，因 RSV、HMPV 和流感导致每 10000 名县居民的年平均住院率分别为 15.01、9.82 和 11.81。
结论
在≥50 岁的成年人中，RSV 和 HMPV 的住院率与流感相关的住院率相似。
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