细胞色素P450系统基础综述。 - Suppr

Basic review of the cytochrome p450 system.

作者信息

McDonnell Anne M, Dang Cathyyen H

机构信息

Brigham and Women's Hospital, Boston, Massachusetts, and Froedtert & The Medical College of Wisconsin, Milwaukee, Wisconsin.

出版信息

J Adv Pract Oncol. 2013 Jul;4(4):263-8. doi: 10.6004/jadpro.2013.4.4.7.

DOI:10.6004/jadpro.2013.4.4.7

PMID:25032007

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4093435/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/4093435/4eac040ed9eb/jadp-04-263-g01.jpg

相似文献

Basic review of the cytochrome p450 system.细胞色素P450系统基础综述。

J Adv Pract Oncol. 2013 Jul;4(4):263-8. doi: 10.6004/jadpro.2013.4.4.7.

Interaction between cytochrome P450 2B1 and cytochrome bs: inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125.细胞色素P450 2B1与细胞色素b5之间的相互作用：合成肽的抑制作用表明P450残基赖氨酸-122和精氨酸-125的作用。

Biochem Biophys Res Commun. 1994 Jun 30;201(3):1090-5. doi: 10.1006/bbrc.1994.1817.

Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.通过共表达NADPH-细胞色素P450还原酶和细胞色素b5优化酵母表达的人肝细胞色素P450 3A4的催化活性

Eur J Biochem. 1992 Jul 1;207(1):109-16. doi: 10.1111/j.1432-1033.1992.tb17027.x.

[Clinical significance of cytochrome P450 genetic polymorphism--part I. Enzymatic system of cytochrome P450 and cytochrome P450 1A2].细胞色素P450基因多态性的临床意义——第一部分。细胞色素P450的酶系统与细胞色素P450 1A2

Ceska Slov Farm. 2011 Jun;60(3):110-5.

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.司来吉兰及其对映体（S）-（+）-N，α-二甲基-N-丙炔基苯乙胺经细胞色素P450 2D6的非典型代谢。

Chem Res Toxicol. 1994 May-Jun;7(3):286-90. doi: 10.1021/tx00039a003.

Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.细胞色素P450 2D6底物氧化机制的多样性。NADPH-细胞色素P450还原酶在催化区域选择性中不存在变构作用。

J Biol Chem. 2001 Oct 26;276(43):39553-61. doi: 10.1074/jbc.M106841200. Epub 2001 Aug 16.

[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].[细胞色素P450蛋白在体外药物代谢研究中的表达系统]

Postepy Hig Med Dosw (Online). 2011 Jun 17;65:367-76. doi: 10.5604/17322693.948845.

Stochastic simulations of the cytochrome P450 catalytic cycle.细胞色素P450催化循环的随机模拟。

J Phys Chem B. 2007 Apr 26;111(16):4251-60. doi: 10.1021/jp071222n. Epub 2007 Apr 3.

From electrochemistry to enzyme kinetics of cytochrome P450.从电化学到细胞色素 P450 的酶动力学。

Biosens Bioelectron. 2018 Dec 15;121:192-204. doi: 10.1016/j.bios.2018.08.040. Epub 2018 Aug 23.

Effects of obesity on the cytochrome P450 enzyme system.肥胖对细胞色素P450酶系统的影响。

Int J Clin Pharmacol Ther. 1999 Jan;37(1):8-19.

引用本文的文献

A scoping review about smoking, smoking cessation and their effects on anti-tuberculosis agents: insights into drug metabolisms, safety, and effectiveness.一项关于吸烟、戒烟及其对抗结核药物影响的范围综述：对药物代谢、安全性和有效性的见解。

Front Pharmacol. 2025 Jul 16;16:1606150. doi: 10.3389/fphar.2025.1606150. eCollection 2025.

Phenoconversion and phenotyping of hepatic cytochrome P450: Implications in predictive precision medicine and personalized therapy.肝细胞色素P450的表型转换与表型分析：对预测性精准医学和个性化治疗的意义。

Hepatol Forum. 2024 Sep 10;6(3):121-128. doi: 10.14744/hf.2023.2023.0047. eCollection 2025.

Sensitivity of Tepotinib to Inhibitors or Inducers of CYP3A4 and P-Gp: Drug Interaction Studies and Physiologically-Based Pharmacokinetic Analysis.替泊替尼对CYP3A4和P-糖蛋白抑制剂或诱导剂的敏感性：药物相互作用研究及基于生理的药代动力学分析

Clin Transl Sci. 2025 Jul;18(7):e70273. doi: 10.1111/cts.70273.

Curcumin and acute myeloid leukemia: a golden hope, updated insights.姜黄素与急性髓系白血病：金色希望，最新见解

Mol Biol Rep. 2025 Jun 11;52(1):583. doi: 10.1007/s11033-025-10692-z.

Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing.开发一种表达四种人类细胞色素P450用于遗传毒性测试的TK6衍生细胞系。

Toxicol In Vitro. 2025 Oct;108:106085. doi: 10.1016/j.tiv.2025.106085. Epub 2025 May 26.

Cutting-edge assays for mirabegron and tadalafil combo therapy for benign prostatic hyperplasia; insilico kinetics approach; multi trait sustainability assessment.用于米拉贝隆和他达拉非联合治疗良性前列腺增生的前沿检测方法；计算机动力学方法；多性状可持续性评估。

BMC Chem. 2025 May 23;19(1):140. doi: 10.1186/s13065-025-01497-z.

Genetic Mutations and Small Bowel Ulcerating Disease: Role in Diagnosis?基因突变与小肠溃疡性疾病：在诊断中的作用？

Curr Gastroenterol Rep. 2025 May 21;27(1):33. doi: 10.1007/s11894-025-00978-4.

Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives.新型槲皮素衍生物的药代动力学预测及细胞毒性

Chem Biodivers. 2025 Aug;22(8):e202500119. doi: 10.1002/cbdv.202500119. Epub 2025 May 9.

In silico drug repurposing of potential antiviral inhibitors targeting methyltransferase (2'-O-MTase) domain of Marburg virus.针对马尔堡病毒甲基转移酶（2'-O-甲基转移酶）结构域的潜在抗病毒抑制剂的计算机药物重新利用研究

In Silico Pharmacol. 2025 Apr 24;13(2):70. doi: 10.1007/s40203-025-00355-z. eCollection 2025.

Drug-Drug Interactions Leading to Tacrolimus Toxicity in a Renal Transplant Patient With COVID-19: The Role of Paxlovid and the Mitigating Use of Phenytoin.药物相互作用导致一名 COVID-19 肾移植患者他克莫司中毒：帕罗韦德的作用及苯妥英的缓解作用

Cureus. 2025 Mar 20;17(3):e80902. doi: 10.7759/cureus.80902. eCollection 2025 Mar.

本文引用的文献

CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.CYP2D6 基因型与内分泌治疗反应性乳腺癌绝经后妇女的关系：乳腺国际研究组 1-98 试验。

J Natl Cancer Inst. 2012 Mar 21;104(6):441-51. doi: 10.1093/jnci/djs125. Epub 2012 Mar 6.

New simvastatin dosing recommendations.新的辛伐他汀给药建议。

Med Lett Drugs Ther. 2011 Aug 25;53(1370):61-2.

Genetic polymorphism and toxicology--with emphasis on cytochrome p450.遗传多态性与毒理学——以细胞色素 p450 为重点。

Toxicol Sci. 2011 Mar;120(1):1-13. doi: 10.1093/toxsci/kfq374. Epub 2010 Dec 13.

Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib.酪氨酸激酶抑制剂伊马替尼、达沙替尼和尼洛替尼的药物相互作用。

Blood. 2011 Feb 24;117(8):e75-87. doi: 10.1182/blood-2010-07-294330. Epub 2010 Sep 1.

OPRM1 and CYP2B6 gene variants as risk factors in methadone-related deaths.阿片受体 μ 型 1 基因和细胞色素 P450 2B6 基因变异与美沙酮相关死亡的风险因素有关。

Clin Pharmacol Ther. 2010 Sep;88(3):383-9. doi: 10.1038/clpt.2010.127. Epub 2010 Jul 28.

Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer.伴随 CYP2D6 抑制剂使用和他莫昔芬依从性对早期乳腺癌乳腺癌复发的影响。

J Clin Oncol. 2010 May 10;28(14):2423-9. doi: 10.1200/JCO.2009.25.0894. Epub 2010 Apr 12.

Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study.选择性 5-羟色胺再摄取抑制剂和接受他莫昔芬治疗的女性乳腺癌死亡率：一项基于人群的队列研究。

BMJ. 2010 Feb 8;340:c693. doi: 10.1136/bmj.c693.

The cytochrome p450 homepage.细胞色素 p450 主页。

Hum Genomics. 2009 Oct;4(1):59-65. doi: 10.1186/1479-7364-4-1-59.

Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.CYP2D6基因多态性与接受他莫昔芬治疗的早期乳腺癌女性患者预后之间的关联。

JAMA. 2009 Oct 7;302(13):1429-36. doi: 10.1001/jama.2009.1420.

Pharmacogenomics of tamoxifen therapy.他莫昔芬治疗的药物基因组学

Clin Chem. 2009 Oct;55(10):1770-82. doi: 10.1373/clinchem.2008.121756. Epub 2009 Jul 2.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Basic review of the cytochrome p450 system.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献