Soleimani Samarkhazan Hamed, Noormohamadi Hanieh, Shafiei Fatemeh Sadat, Pilehvari Niloofar, Aghaei Amir Hossein, Mohammadi Mohammad Hossein, Shanaki Mehrnoosh
Student Research Committee, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2025 Jun 11;52(1):583. doi: 10.1007/s11033-025-10692-z.
Acute myeloid leukemia (AML) is marked by uncontrolled growth of malignant cells in the bone marrow, presenting a major challenge in hematology despite treatment advances. Curcumin, a polyphenol from turmeric, shows promise as an anticancer agent with multiple mechanisms targeting pathways like NF-κB, STAT3, PI3K/AKT, and MAPK. This review highlights curcumin's antileukemic effects, including apoptosis induction, cell proliferation inhibition, and angiogenesis modulation. Although low bioavailability limits its clinical use, nanoformulations such as liposomes and micelles have improved curcumin's stability and uptake. Combining curcumin with standard chemotherapies has shown synergistic effects, enhancing anticancer efficacy. Preclinical studies consistently demonstrate curcumin's antileukemic impact in AML cell lines and animal models, showing reduced tumor load and prolonged survival. Ongoing clinical trials are assessing curcumin's safety and efficacy in AML patients, with early results indicating potential. However, larger randomized trials are needed for confirmation. In conclusion, curcumin's anticancer properties and safety profile make it a valuable candidate for AML treatment. Further research is necessary to refine delivery methods, optimize combination therapies, and substantiate its role through clinical trials.
急性髓系白血病（AML）的特征是骨髓中恶性细胞的不受控制生长，尽管治疗取得了进展，但仍是血液学中的一项重大挑战。姜黄素是一种来自姜黄的多酚，作为一种抗癌剂显示出前景，它通过多种机制靶向如NF-κB、STAT3、PI3K/AKT和MAPK等信号通路。本综述强调了姜黄素的抗白血病作用，包括诱导细胞凋亡、抑制细胞增殖和调节血管生成。尽管低生物利用度限制了其临床应用，但脂质体和胶束等纳米制剂提高了姜黄素的稳定性和摄取。将姜黄素与标准化疗联合使用已显示出协同作用，增强了抗癌疗效。临床前研究一致证明姜黄素对AML细胞系和动物模型具有抗白血病作用，表现为肿瘤负荷降低和生存期延长。正在进行的临床试验正在评估姜黄素对AML患者的安全性和疗效，早期结果显示出潜力。然而，需要更大规模的随机试验来证实。总之，姜黄素的抗癌特性和安全性使其成为AML治疗的一个有价值的候选药物。有必要进一步研究以优化给药方法、优化联合治疗方案，并通过临床试验证实其作用。
