重新评估基底神经节功能与功能障碍的模型。
Reassessing models of basal ganglia function and dysfunction.
作者信息
Nelson Alexandra B, Kreitzer Anatol C
机构信息
The Gladstone Institutes, San Francisco, California 94158; email:
出版信息
Annu Rev Neurosci. 2014;37:117-35. doi: 10.1146/annurev-neuro-071013-013916.
Abstract
The basal ganglia are a series of interconnected subcortical nuclei. The function and dysfunction of these nuclei have been studied intensively in motor control, but more recently our knowledge of these functions has broadened to include prominent roles in cognition and affective control. This review summarizes historical models of basal ganglia function, as well as findings supporting or conflicting with these models, while emphasizing recent work in animals and humans directly testing the hypotheses generated by these models.
摘要
基底神经节是一系列相互连接的皮质下核团。这些核团的功能及功能障碍在运动控制方面已得到深入研究，但最近我们对这些功能的认识有所拓展，包括其在认知和情感控制中也发挥着重要作用。本综述总结了基底神经节功能的历史模型，以及支持或与这些模型相矛盾的研究结果，同时强调了近期在动物和人类中直接检验这些模型所产生假设的研究工作。
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